What is the research behind aerobic trainability?

At DNAfit, we have a strict inclusion protocol to evaluate whether a gene will be included in our reports. Each gene must have a minimum of 3-peer reviewed studies in humans demonstrating the effect, there must be a consensus on that effect, and that effect must be modifiable through an environmental and lifestyle change.

Below is a sample of our evidence base for aerobic trainability:

Familial aggregation of stroke volume and cardiac output during submaximal exercise: the HERITAGE Family Study

Polymorphisms of the vascular endothelial growth factor gene (VEGF) and aerobic performance in athletes 

Does genetic variation in PPARGC1A affect exercise-induced changes in ventilatory thresholds and metabolic syndrome?